Publication
Title
Numerical validation of a new method to assess aortic pulse wave velocity from a single recording of a brachial artery waveform with an occluding cuff
Author
Abstract
Recently a new method has been proposed as a tool to measure arterial pulse wave velocity (PWV), a measure of the stiffness of the large arteries and an emerging parameter used as indicator of clinical cardiovascular risk. The method is based on measurement of brachial blood pressure during supra-systolic pressure inflation of a simple brachial cuff [the device is known as the Arteriograph (Tensiomed, Budapest, Hungary)]. This occlusion yields pronounced first and secondary peaks in the pressure waveform, the latter ascribed to a reflection from the aortic bifurcation, and PWV is calculated as the ratio of twice the jugulum-symphysis distance and the time difference between the two peaks. To test the validity of this working principle, we used a numerical model of the arterial tree to simulate pressures and flows in the normal configuration, and in a configuration with an occluded brachial artery. A pronounced secondary peak was indeed found in the brachial pressure signal of the occluded model, but its timing was only related to brachial stiffness and not to aortic stiffness. We also compared PWVs calculated with three different methods: PWVATG (~Arteriograph principle), PWVcarfem (~carotidfemoral PWV, the current clinical gold standard method), and PWVtheor (~BramwellHill equation). Both PWVATG (R 2 = 0.94) and PWVcarfem (R 2 = 0.95) correlated well with PWVtheor, but their numerical values were lower (by 2.17 ± 0.42 and 1.08 ± 0.70 m/s for PWVATG and PWVcarfem, respectively). In conclusion, our simulations question the working principle of the Arteriograph. Our data indicate that the method picks up wave reflection phenomena confined to the brachial artery, and derived values of PWV rather reflect the stiffness of the brachial arteries.
Language
English
Source (journal)
Annals of biomedical engineering. - New York, N.Y.
Publication
New York, N.Y. : 2010
ISSN
0090-6964
Volume/pages
38:3(2010), p. 876-888
ISI
000275746900030
Full text (Publisher's DOI)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 28.05.2010
Last edited 04.08.2017
To cite this reference