Title
Perfusion and diffusion limitations in middle ear gas exchange: the exchange of <tex>$CO_{2}$</tex> as a test case Perfusion and diffusion limitations in middle ear gas exchange: the exchange of <tex>$CO_{2}$</tex> as a test case
Author
Faculty/Department
Faculty of Sciences. Physics
Publication type
article
Publication
Amsterdam ,
Subject
Physics
Biology
Source (journal)
Hearing research. - Amsterdam
Volume/pages
265(2010) :1/2 , p. 11-14
ISSN
0378-5955
ISI
000279092000002
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
A long standing debate on perfusion/diffusion limitations in the context of middle ear (ME) gas exchange was revisited using data obtained from previous iso-pressure gas-exchange measurements in different mammals. We tried to determine whether the exchange of CO2 in the ME is limited by perfusion or by diffusion by comparing the mass specific cardiac output (View the MathML source) and the mass specific initial CO2 flow rate into air-washed MEs (View the MathML source) of rabbits and rats. Based on previously published allometry at rest, the View the MathML source was 0.154 mL/(min g) in rabbits (mean body weight: 2800 g) and 0.259 mL/(min g) in rats (mean body weight: 179.1 g); View the MathML source (Δt = 0) was 0.109 ± 0.047 μL/(h g) in rabbits (n = 16) and 0.170 ± 0.094 μL/(h g) in rats (n = 9). Similar ratios were found when an allometric comparison was made between the ratio of View the MathML source (Δt = 0) (not, vert, similar0.64), and the ratio of View the MathML sources (not, vert, similar0.59) in rabbits and rats. If the active mucosal surface areas of MEs of rabbits and rats are directly proportional to their masses as are the masses of their hearts and if their View the MathML sources are proportional to the rates of blood flows in the ME mucosa, these results support the assumption that the exchange of CO2 in the ME of mammals is mainly perfusion (and not diffusion) dependent.
E-info
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