Title Perfusion and diffusion limitations in middle ear gas exchange: the exchange of $CO_{2}$ as a test casePerfusion and diffusion limitations in middle ear gas exchange: the exchange of $CO_{2}$ as a test case Author Marcusohn, Yael Ar, Amos Dirckx, Joris J.J. Faculty/Department Faculty of Sciences. Physics Research group Biophysics and Biomedical Physics Department of Physics Publication type article Publication 2010Amsterdam, 2010 Subject Physics Biology Source (journal) Hearing research. - Amsterdam Volume/pages 265(2010):1/2, p. 11-14 ISSN 0378-5955 ISI 000279092000002 Carrier E Target language English (eng) Full text (Publishers DOI) Affiliation University of Antwerp Abstract A long standing debate on perfusion/diffusion limitations in the context of middle ear (ME) gas exchange was revisited using data obtained from previous iso-pressure gas-exchange measurements in different mammals. We tried to determine whether the exchange of CO2 in the ME is limited by perfusion or by diffusion by comparing the mass specific cardiac output (View the MathML source) and the mass specific initial CO2 flow rate into air-washed MEs (View the MathML source) of rabbits and rats. Based on previously published allometry at rest, the View the MathML source was 0.154 mL/(min g) in rabbits (mean body weight: 2800 g) and 0.259 mL/(min g) in rats (mean body weight: 179.1 g); View the MathML source (Δt = 0) was 0.109 ± 0.047 μL/(h g) in rabbits (n = 16) and 0.170 ± 0.094 μL/(h g) in rats (n = 9). Similar ratios were found when an allometric comparison was made between the ratio of View the MathML source (Δt = 0) (not, vert, similar0.64), and the ratio of View the MathML sources (not, vert, similar0.59) in rabbits and rats. If the active mucosal surface areas of MEs of rabbits and rats are directly proportional to their masses as are the masses of their hearts and if their View the MathML sources are proportional to the rates of blood flows in the ME mucosa, these results support the assumption that the exchange of CO2 in the ME of mammals is mainly perfusion (and not diffusion) dependent. E-info http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000279092000002&DestLinkType=RelatedRecords&DestApp=ALL_WOS&UsrCustomerID=ef845e08c439e550330acc77c7d2d848 http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000279092000002&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=ef845e08c439e550330acc77c7d2d848 http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000279092000002&DestLinkType=CitingArticles&DestApp=ALL_WOS&UsrCustomerID=ef845e08c439e550330acc77c7d2d848 Handle