|
Title
|
|
|
|
Antimicrobial drug use and resistance in Europe
|
|
|
Author
|
|
|
|
|
|
|
Institution/Organisation
|
|
|
|
European Antimicrobial Resistance Surveillance System
European Surveillance of Antimicrobial Consumption Project Groups
|
|
|
Abstract
|
|
|
|
| Our study confronts the use of antimicrobial agents in ambulatory care with the resistance trends of 2 major pathogens, Streptococcus pneumoniae and Escherichia coli, in 21 European countries in 20002005 and explores whether the notion that antimicrobial drug use determines resistance can be supported by surveillance data at national aggregation levels. The data obtained from the European Surveillance of Antimicrobial Consumption and the European Antimicrobial Resistance Surveillance System suggest that variation of consumption coincides with the occurrence of resistance at the country level. Linear regression analysis showed that the association between antimicrobial drug use and resistance was specific and robust for 2 of 3 compound pathogen combinations, stable over time, but not sensitive enough to explain all of the observed variations. Ecologic studies based on routine surveillance data indicate a relation between use and resistance and support interventions designed to reduce antimicrobial drug consumption at a national level in Europe. |
|
|
|
Language
|
|
|
|
English
|
|
|
Source (journal)
|
|
|
|
Emerging infectious diseases / National Center for Infectious Diseases. Centers for Disease Control and Prevention. - Atlanta, Ga
|
|
|
Publication
|
|
|
|
Atlanta, Ga
:
2008
|
|
|
ISSN
|
|
|
|
1080-6040
1080-6059
|
|
|
DOI
|
|
|
|
10.3201/EID1411.070467
|
|
|
Volume/pages
|
|
|
|
14
:11
(2008)
, p. 1722-1730
|
|
|
ISI
|
|
|
|
000260617000007
|
|
|
Full text (Publisher's DOI)
|
|
|
|
|
|
|
Full text (open access)
|
|
|
|
|
|