Title
Young infants with atopic dermatitis can display sensitization to Cor a 9, a 11S legumin-like seed-storage protein from hazelnut (**Corylus avellana**)Young infants with atopic dermatitis can display sensitization to Cor a 9, a 11S legumin-like seed-storage protein from hazelnut (**Corylus avellana**)
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Research group
Translational Pathophysiological Research (TPR)
Immunologie, allergologie, reumatologie
Laboratory Experimental Medicine and Pediatrics (LEMP)
Faculteit Geneeskunde
Publication type
article
Publication
Copenhagen,
Subject
Pharmacology. Therapy
Source (journal)
Pediatric allergy and immunology. - Copenhagen
Volume/pages
22(2011):2, p. 196-201
ISSN
0905-6157
ISI
000287531300007
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Allergy to hazelnut (Corylus avellana) can be severe and occur at young age. Atopic dermatitis (AD) can involve sensitization to various foods. The objective is to investigate the pattern of hazelnut sensitization in infants with AD. Sera of 34 infants all under 1 and suffering from AD were selected according to prior specific IgE results. Twenty-nine infants were sensitized for traditional food allergens, five were not. From the 29 infants with a sensitization to at least one food allergen, 20 demonstrated IgE reactivity to hazelnut. All sera were analyzed with the allergen microarray immunoassay (ImmunoCAP ISAC). The results are 12 (60%) of the children with IgE reactivity to hazelnut demonstrated sensitization to Cor a 9, the 11S legumin-like seed-storage protein from hazelnut. In these infants, no sensitization to Cor a 1, the homologue of the major allergen from birch pollen Bet v 1 (Betula verrucosa), or the lipid transfer protein (Cor a 8) from hazelnut was demonstrable. Half of the children sensitized to Cor a 9 demonstrated IgE reactivity to its homologue in peanut (Arachis hypogaea; Ara h 3) from which five were also sensitized to Gly m 6 from soy (Glycine max). None of the infants with AD without IgE reactivity to hazelnut demonstrated sensitization to Cor a 1, 8, or 9. The conclusion is young infants with atopic dermatitis sensitized to hazelnut can already display IgE reactivity to Cor a 9, a potentially dangerous hazelnut component. The mechanism(s) of this early sensitization and its clinical significance remain elusive.
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