Publication
Title
Selective removal of macrophages in atherosclerotic plaques as a pharmacological approach for plaque stabilization: benefits vs. potential complications
Author
Abstract
Atherosclerotic plaque destabilization is a major cause of unstable angina, myocardial infarction, and sudden cardiac death. Macrophages, which are an essential component of unstable plaques, play a pivotal role in the destabilization process, whereas smooth muscle cells contribute to plaque stability. Selective removal of macrophages is therefore an interesting pharmacological objective to stabilize vulnerable, rupture-prone lesions. Pharmacological agents such as clodronate, nitric oxide donors, mammalian target of rapamycin (mTOR) inhibitors, protein synthesis inhibitors, and statins, that are capable of selectively depleting macrophages in atherosclerotic plaques without affecting smooth muscle or endothelial cells, have recently been identified. This review focuses on the mechanism of action of these drugs as well as on the potential pitfalls of drug-induced macrophage depletion.
Language
English
Source (journal)
Current vascular pharmacology
Publication
2010
ISSN
1570-1611
Volume/pages
8:4(2010), p. 495-508
ISI
000280122900006
Full text (Publisher's DOI)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 18.06.2010
Last edited 13.11.2017
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