Publication
Title
A population-based study of familial Alzheimer's disease : linkage to chromosome 14, 19 and 21
Author
Abstract
Linkage of Alzheimer disease (AD) to DNA markers on chromosomes 14, 19, and 21 was studied in 10 families in which the disease was apparently inherited as an autosomal dominant trait. Families were derived from a Dutch population-based epidemiologic study of early-onset AD, Although in all probands the onset of AD was at or before age 65 years, the mean age at onset was after age 65 years in four families (referred to as ''LOAD''). Among the six families with early-onset AD (referred to as ''EOAD,'' i.e., mean age of onset of AD of relatives was at or before age 65 years), conclusive linkage to 14q24.3 was found in one family with a very early onset (around 47 years), while linkage to the same region was excluded in two other families. For the LOAD families, predominantly negative lod scores were obtained, and the overall lod score excluded linkage to chromosome 14. The results with markers on chromosome 19 and chromosome 21 were not conclusive for EOAD and LOAD. The findings of our study confirm genetic heterogeneity within familial EOAD.
Language
English
Source (journal)
The American journal of human genetics / American Society of Human Genetics [Bethesda, Md] - New York, N.Y., 1949, currens
Publication
New York, N.Y. : 1994
ISSN
0002-9297 [print]
1537-6605 [online]
Volume/pages
55:4(1994), p. 714-727
ISI
A1994PJ02700015
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 08.10.2008
Last edited 18.07.2017
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