Title
Advances in the systemic treatment of head and neck cancers Advances in the systemic treatment of head and neck cancers
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Philadelphia, Pa ,
Subject
Human medicine
Source (journal)
Current opinion in oncology. - Philadelphia, Pa
Volume/pages
22(2010) :3 , p. 200-205
ISSN
1040-8746
ISI
000277380300007
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Purpose of review: To summarize the recent literature on the treatment of recurrent and metastatic squamous cell carcinoma of the head and neck. Recent findings: Multiple targeted therapies and novel combinations of chemotherapeutic agents were tested. Summary: In a large randomized phase III trial, the addition of cetuximab to platin-based chemotherapy led to a significant prolongation of overall survival. The combination of cetuximab and platin/5-fluorouracil should be considered the current standard first-line regimen. In contrast, the results with oral tyrosine kinase inhibitors and other targeted agents have been disappointing thus far.
E-info
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