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Title
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Advances in the systemic treatment of head and neck cancers
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Author
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Abstract
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| Purpose of review: To summarize the recent literature on the treatment of recurrent and metastatic squamous cell carcinoma of the head and neck. Recent findings: Multiple targeted therapies and novel combinations of chemotherapeutic agents were tested. Summary: In a large randomized phase III trial, the addition of cetuximab to platin-based chemotherapy led to a significant prolongation of overall survival. The combination of cetuximab and platin/5-fluorouracil should be considered the current standard first-line regimen. In contrast, the results with oral tyrosine kinase inhibitors and other targeted agents have been disappointing thus far. |
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Language
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English
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Source (journal)
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Current opinion in oncology. - Philadelphia, Pa
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Publication
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Philadelphia, Pa
:
2010
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ISSN
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1040-8746
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DOI
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10.1097/CCO.0B013E3283376E15
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Volume/pages
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22
:3
(2010)
, p. 200-205
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ISI
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000277380300007
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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