Publication
Title
Synthesis and evaluation of -halogenated analogues of 3-(acetylhydroxyamino)propylphosphonic acid (FR900098) as antimalarials
Author
Abstract
Three α-halogenated analogues of 3-(acetylhydroxyamino)propylphosphonic acid (FR900098) have been synthesized from diethyl but-3-enylphosphonate using a previously described method for the α-halogenation of alkylphosphonates. These analogues were evaluated for antimalarial potential in vitro against Plasmodium falciparum and in vivo in the P. berghei mouse model. All three analogues showed higher in vitro and/or in vivo potency than the reference compounds.
Language
English
Source (journal)
Journal of medicinal chemistry. - Washington, D.C., 1963, currens
JOURNAL OF MEDICINAL CHEMISTRY
Publication
Washington, D.C. : 2010
ISSN
0022-2623
Volume/pages
53:14(2010), p. 5342-5346
ISI
000279787200023
Full text (Publisher's DOI)
UAntwerpen
Faculty/Department
Research group
[E?say:metaLocaldata.cgzprojectinf]
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 23.06.2010
Last edited 11.10.2017
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