Title
Medical and surgical management of paraneoplastic pyoderma gangrenosum: a case report and review of the literature Medical and surgical management of paraneoplastic pyoderma gangrenosum: a case report and review of the literature
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Leuven ,
Subject
Human medicine
Source (journal)
Acta clinica Belgica. - Leuven, 1946 - 1997
Volume/pages
65(2010) :1 , p. 37-40
ISSN
0001-5512
ISI
000276999200005
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
We present a case of a 44 year old male with pyoderma gangrenosum (PG) presenting simultaneously with diagnosis of acute leukemia. His skin disease was stabilized with corticosteroids and most lesions cleared after chemotherapy-induced remission of the malignancy, but the largest lesion remained necrotic. Surgical treatment of the large necrotic ulcer included debridement followed by split-thickness skin graft while maintaining corticoid therapy. Unfortunately, relapse of the pyoderma gangrenosum with bullous lesions heralded relapse of the ultimately fatal malignancy. This case illustrates: 1. PG presenting simultaneously with a haematologic malignancy 2. Relapse with atypical bullous lesions with return of the malignancy and 3. The use of surgical modalities in managing patients with PG, a disease notorious for surgical complications.
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