Title
Kinetics of maternal antibodies against rubella and varicella in infantsKinetics of maternal antibodies against rubella and varicella in infants
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Research group
Vaccine & Infectious Disease Institute (VAXINFECTIO)
Publication type
article
Publication
Amsterdam,
Subject
Human medicine
Source (journal)
Vaccine / International Society for Vaccines. - Amsterdam
Volume/pages
29(2011):11, p. 2222-2226
ISSN
0264-410X
ISI
000288731000033
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Kinetics of maternal rubella and varicella antibodies in 213 motherinfant pairs are described in a longitudinal study in Belgium. Blood samples are taken at 7 time points (week 36 of pregnancy, birth (cord), 1, 3, 6, 9, and 12 months), and analyzed for anti-rubella IgG and anti-varicella IgG by enzyme linked immunosorbent assay (ELISA). A generalized exponential model is used to analyse maternal antibody decay in infants. Model based, the mean duration of passive immunity is 2.1 months for rubella and 2.4 months for varicella. Infants are susceptible at young age for rubella, a disease with high vaccination coverage, as well as for varicella, an endemic disease in Western Europe.
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