Publication
Title
**GCH1** haplotype determines vascular and plasma biopterin availability in coronary artery disease: effects on vascular superoxide production and endothelial function
Author
Abstract
Objectives This study sought to determine the effects of endogenous tetrahydrobiopterin (BH4) bioavailability on endothelial nitric oxide synthase (eNOS) coupling, nitric oxide (NO) bioavailability, and vascular superoxide production in patients with coronary artery disease (CAD). Background GTP-cyclohydrolase I, encoded by the GCH1 gene, is the rate-limiting enzyme in the biosynthesis of BH4, an eNOS cofactor important for maintaining enzymatic coupling. We examined the associations between haplotypes of the GCH1 gene, GCH1 expression and biopterin levels, and the effects on endothelial function and vascular superoxide production. Methods Blood samples and segments of internal mammary arteries and saphenous veins were obtained from patients with CAD undergoing coronary artery bypass grafting (n = 347). The GCH1 haplotypes were defined by 3 polymorphisms: rs8007267G
Language
English
Source (journal)
Journal of the American College of Cardiology. - New York, N.Y.
Publication
New York, N.Y. : 2008
ISSN
0735-1097
Volume/pages
52:2(2008), p. 158-165
ISI
000257290800011
Full text (Publisher's DOI)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 20.08.2010
Last edited 08.07.2017
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