Title
Puumala hantavirus and **Myodes glareolus** in northern Europe: no evidence of co-divergence between genetic lineages of virus and hostPuumala hantavirus and **Myodes glareolus** in northern Europe: no evidence of co-divergence between genetic lineages of virus and host
Author
Faculty/Department
Faculty of Sciences. Biology
Research group
Evolutionary ecology group (EVECO)
Publication type
article
Publication
London,
Subject
Biology
Source (journal)
Journal of general virology. - London
Volume/pages
91(2010):5, p. 1262-1274
ISSN
0022-1317
ISI
000277761100021
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
The genus Hantavirus (family Bunyaviridae) includes negative-strand RNA viruses that are carried by persistently infected rodent and insectivore species. Puumala virus (PUUV), carried by bank voles (Myodes glareolus), is a pathogenic hantavirus that causes outbreaks of mild haemorrhagic fever with renal syndrome across Europe. In northern Europe, PUUV is represented by several genetic lineages that are maintained by distinct phylogroups of bank voles. The present study describes sequences of new PUUV strains recovered from northern and southern regions of Scandinavia and compares phylogenetic relationships between north-European PUUV strains and M. glareolus. This analysis revealed contradictions in phylogenetic clustering and remarkable differences in estimated divergence times between the lineages of PUUV and its host, suggesting that the established PUUV lineages did not co-diverge with the distinct phylogroups of M. glareolus that carry them at present.
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