Title
Cumulative live-birth delivery after IVF/ICSI since the progressive introduction of single-embryo transfer Cumulative live-birth delivery after IVF/ICSI since the progressive introduction of single-embryo transfer
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Cambridge ,
Subject
Biology
Human medicine
Source (journal)
Reproductive biomedicine online. - Cambridge
Volume/pages
20(2010) :6 , p. 836-842
ISSN
1472-6483
1472-6483
ISI
000279494800018
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
The only way to decrease the incidence of multiple pregnancies in the IVF/intracytoplasmic sperm injection (ICSI) population is to introduce single-embryo transfer (SET). This study investigated the impact of the progressive introduction of SET for the whole IVF/ICSI population from the patients point of view by calculating the cumulative live-birth delivery rate. During a 5-year period (20012005), the outcome of 2164 cycles with oocyte aspiration in 1047 patients was analysed. A subanalysis was made to calculate the additional effect of frozenthawed cycles. Survival analysis was performed with the KaplanMeier method and the endpoint was live-birth delivery. In this 5-year period, the cumulative live-birth delivery rate per patient was 51% after three IVF/ICSI cycles and 58% after six cycles. With a more permissive method of survival analysis, these results were 64% and 85%, respectively. The additional effect of the frozenthawed cycles since reimbursement was only 5%. SET was progressively introduced in this period leading to a twin live-birth delivery rate of only 6.7%. It is concluded that a favourable outcome was observed for the cumulative live-birth delivery rate since the introduction of SET but with a disappointing additional effect of the frozenthawed cycles.
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