Publication
Title
Epigenetic remedies by dietary phytochemicals against inflammatory skin disorders: myth or reality?
Author
Abstract
While many botanicals have been used during thousands of years in various cultures for the treatment of several inflammatory conditions, wound healing or preserving skin beauty, their active ingredients and their mechanisms of action are less well characterized. It is known that throughout life, environmental conditions and dietary compounds influence gene expression. Only recently it has been observed that exposure to specific phytochemicals can affect gene expression via reversible epigenetic mechanisms and gets recorded in our "epigenome" through life. Epigenetics refers to heritable phenotypical differences or changes in gene expression that are not attributable to changes in DNA sequence, but rather depend on variations in DNA methylation, chromatin structure or microRNA profiles. As such, our dietary epigenetic imprint superposed on our genome may rewire gene expression patterns in the body and the host immune system, and protect against inflammatory disorders, cancer and ageing. This has recently launched reexploration of nutritional, botanical or phytopharmaceutical compounds for epigenetic effects to identify promising nutraceuticals or cosmeceuticals which could (re)program stem cell differentiation, wound healing, skin regeneration, tissue homeostasis, or "correct" epigenetic marks responsible for inflammatory skin disorders and ageing.
Language
English
Source (journal)
Current drug metabolism : the international journal for timely in-depth reviews on drug metabolism.. - Schiphol :
Publication
Sharjah : Bentham science publ ltd, 2010
ISSN
1389-2002
Volume/pages
11:5(2010), p. 436-450
ISI
000279638600006
Full text (Publisher's DOI)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 03.09.2010
Last edited 10.01.2018
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