Title
Current status on Alzheimer disease molecular genetics: from past, to present, to future Current status on Alzheimer disease molecular genetics: from past, to present, to future
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences . Biomedical Sciences
Publication type
article
Publication
Oxford ,
Subject
Human medicine
Source (journal)
Human molecular genetics. - Oxford
Volume/pages
19(2010) :1 , p. 1-11
ISSN
0964-6906
ISI
000279004800002
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Linkage studies, candidate gene and whole-genome association studies have resulted in a tremendous amount of putative risk genes for Alzheimer's disease (AD). Yet, besides the three causal genesamyloid precursor protein and presenilin 1 and 2 genesand one risk gene apolipoprotein E (APOE), no single functional risk variant was identified. Discussing the possible involvement of rare alleles and other types of genetic variants, this review summarizes the current knowledge on the genetic spectrum of AD and integrates different approaches and recent discoveries by genome-wide association studies.
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