Publication
Title
Current status on Alzheimer disease molecular genetics: from past, to present, to future
Author
Abstract
Linkage studies, candidate gene and whole-genome association studies have resulted in a tremendous amount of putative risk genes for Alzheimer's disease (AD). Yet, besides the three causal genesamyloid precursor protein and presenilin 1 and 2 genesand one risk gene apolipoprotein E (APOE), no single functional risk variant was identified. Discussing the possible involvement of rare alleles and other types of genetic variants, this review summarizes the current knowledge on the genetic spectrum of AD and integrates different approaches and recent discoveries by genome-wide association studies.
Language
English
Source (journal)
Human molecular genetics. - Oxford
Publication
Oxford : 2010
ISSN
0964-6906
Volume/pages
19:1(2010), p. 1-11
ISI
000279004800002
Full text (Publisher's DOI)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 14.09.2010
Last edited 19.09.2017
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