Publication
Title
Molecular pathways of frontotemporal lobar degeneration
Author
Abstract
Frontotemporal lobar degeneration (FTLD) is a neurodegenerative condition that predominantly affects behavior, social awareness, and language. It is characterized by extensive heterogeneity at the clinical, pathological, and genetic levels. Recognition of these levels of heterogeneity is important for proper disease management. The identification of progranulin and TDP-43 as key proteins in a significant proportion of FTLD patients has provided the impetus for a wealth of studies probing their role in neurodegeneration. This review highlights the most recent developments and future directions in this field and puts them in perspective of the novel insights into the neurodegenerative process, which have been gained from related disorders, e.g., the role of FUS in amyotrophic lateral sclerosis
Language
English
Source (journal)
Annual review of neuroscience. - Palo Alto, Calif.
Publication
Palo Alto, Calif. : 2010
ISSN
0147-006X
Volume/pages
33(2010), p. 71-88
ISI
000283330200004
Full text (Publishers DOI)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 16.09.2010
Last edited 23.05.2017
To cite this reference