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Title
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No association of **PGRN** 3'UTRrs5848 in frontotemporal lobar degeneration
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Author
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Abstract
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| Frontotemporal lobar degeneration (FTLD) is a highly familial neurodegenerative disease. It has been claimed that homozygosity of the SNP rs5848 located in the 3UTR of progranulin increases risk for FTLD. We have attempted to replicate the association of rs5848 in three independent FTLD cohorts. No association of rs5848 with FTLD was observed in any individual cohort nor was any observed when the data was combined. These data argue that rs5848 is not a risk factor for FTLD. |
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Language
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English
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Source (journal)
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Neurobiology of aging. - Fayetteville, N.Y.
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Publication
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Fayetteville, N.Y.
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2011
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ISSN
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0197-4580
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DOI
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10.1016/J.NEUROBIOLAGING.2009.04.009
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Volume/pages
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32
:4
(2011)
, p. 754-755
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ISI
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000289956600018
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Full text (Publisher's DOI)
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