**PCM1** and schizophrenia: a replication study in the Northern Swedish population
Van Den Bossche, Maarten J.A.
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences . Biomedical Sciences
American journal of medical genetics: part B: neuropsychiatric genetics. - Bognor Regis
, p. 1240-1243
University of Antwerp
Previous studies implicated centrosomal dysfunction as a source of various neuropsychiatric disorders, including schizophrenia (SZ). Two recent reports [Gurling et al., 2006; Datta et al., 2008. Mol Psychiatry] described an association between polymorphisms in the PCM1 gene and SZ in a UK/Scottish population. In this study, we aimed to replicate these findings in a Northern Swedish association sample of 486 research subjects with SZ and 512 unrelated control individuals. We genotyped 12 previously described SNPmarkers and carried out haplotype analyses using the same multi-marker haplotypes previously reported. Though we could not replicate the association with SNPs rs445422 and rs208747, we did observe a significant protective association with intronic SNP rs13276297. Furthermore, we performed a metaanalysis comprising 1,794 SZ patients and 1,553 controls, which confirmed the previously reported association with rs445422 and rs208747. These data provide further evidence that PCM1 though certainly not a major risk factor in the Northern Swedish populationcannot be ruled out as a contributor to SZ risk and/or protection, and deserves further replication in larger populations to elucidate its role in disease etiology.