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Title
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**PCM1** and schizophrenia: a replication study in the Northern Swedish population
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Author
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Abstract
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| Previous studies implicated centrosomal dysfunction as a source of various neuropsychiatric disorders, including schizophrenia (SZ). Two recent reports [Gurling et al., 2006; Datta et al., 2008. Mol Psychiatry] described an association between polymorphisms in the PCM1 gene and SZ in a UK/Scottish population. In this study, we aimed to replicate these findings in a Northern Swedish association sample of 486 research subjects with SZ and 512 unrelated control individuals. We genotyped 12 previously described SNPmarkers and carried out haplotype analyses using the same multi-marker haplotypes previously reported. Though we could not replicate the association with SNPs rs445422 and rs208747, we did observe a significant protective association with intronic SNP rs13276297. Furthermore, we performed a metaanalysis comprising 1,794 SZ patients and 1,553 controls, which confirmed the previously reported association with rs445422 and rs208747. These data provide further evidence that PCM1 though certainly not a major risk factor in the Northern Swedish populationcannot be ruled out as a contributor to SZ risk and/or protection, and deserves further replication in larger populations to elucidate its role in disease etiology. |
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Language
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English
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Source (journal)
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American journal of medical genetics: part B: neuropsychiatric genetics. - Bognor Regis
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Publication
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Bognor Regis
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2010
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ISSN
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1552-4841
[print]
1552-485X
[online]
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Volume/pages
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153B
:6
(2010)
, p. 1240-1243
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ISI
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000281131300015
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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