Publication
Title
**In vitro** profiling of pramiconazole and in vivo evaluation in **Microsporum canis** dermatitis and Candida albicans vaginitis laboratory models
Author
Abstract
The triazole antifungal pramiconazole (Stiefel, a GSK company) was compared with itraconazole, miconazole and terbinafine in vitro and in vivo. A potent in vitro activity against Candida spp. (IC50 0.04-1.83 μM) and Microsporum and Trichophyton spp. (IC50 0.15-1.34 μM) was obtained, however, not against other filamentous moulds and zygomycetes. In the M. canis guinea pig model and C. albicans vulvovaginitis rat model, pramiconazole was superior to the reference compounds after oral and topical administration.
Language
English
Source (journal)
Antimicrobial agents and chemotherapy. - Washington, D.C.
Publication
Washington, D.C. : 2010
ISSN
0066-4804
Volume/pages
54:11(2010), p. 4927-4929
ISI
000284155000060
Full text (Publisher's DOI)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 13.10.2010
Last edited 14.07.2017
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