Title
**In vitro** profiling of pramiconazole and in vivo evaluation in **Microsporum canis** dermatitis and Candida albicans vaginitis laboratory models
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Pharmacy
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences . Biomedical Sciences
Publication type
article
Publication
Washington, D.C. ,
Subject
Human medicine
Source (journal)
Antimicrobial agents and chemotherapy. - Washington, D.C.
Volume/pages
54(2010) :11 , p. 4927-4929
ISSN
0066-4804
ISI
000284155000060
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
The triazole antifungal pramiconazole (Stiefel, a GSK company) was compared with itraconazole, miconazole and terbinafine in vitro and in vivo. A potent in vitro activity against Candida spp. (IC50 0.04-1.83 μM) and Microsporum and Trichophyton spp. (IC50 0.15-1.34 μM) was obtained, however, not against other filamentous moulds and zygomycetes. In the M. canis guinea pig model and C. albicans vulvovaginitis rat model, pramiconazole was superior to the reference compounds after oral and topical administration.
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