Publication
Title
Dietary-dependent changes in the enteric nervous system and endothelium of premature piglets
Author
Abstract
After birth, intestinal morphology and function have to adapt at a high pace. This remodelling is more challenging in low birth weight neonates or in preterms, where it may result in necrotizing enterocolitis (NEC). We hypothesized that in the preterm piglet, feeding induces maladaptations of the enteric nervous system (ENS) and vasculature. Using image analysis, the densities of neurons expressing VIP, glial cells containing GFAP and the endothelium containing eNOS on immunohistochemically stained small intestinal sections of preterm 1) unfed piglets, 2) piglets receiving total parenteral nutrition (TPN) for 23 days and 3) piglets fed 2 days sow's colostrum (SOW) or formulated milk (FOR) following TPN were estimated. After enteral feeding, the ENS and vascular endothelium grew in the same order as the intestine. However, feeding formula increased the density of VIP'ergic myenteric neurons, lowered eNOS in the endothelium and resulted in a reactive gliosis. In conclusion, formula induces destructive changes in the immature small intestine, whereas colostrum prevents their occurrence. These conditions may be among the factors that predispose to NEC.
Language
English
Source (journal)
Livestock science. - Amsterdam, 2006, currens
Publication
Amsterdam : 2010
ISSN
1871-1413
Volume/pages
133:1/3(2010), p. 23-25
ISI
000284726000005
Full text (Publisher's DOI)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 13.10.2010
Last edited 07.11.2017
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