Title
Rates of bronchopulmonary dysplasia in very preterm neonates in Europe: results from the MOSAIC Cohort Rates of bronchopulmonary dysplasia in very preterm neonates in Europe: results from the MOSAIC Cohort
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Subject
Human medicine
Source (journal)
Neonatology
Volume/pages
99(2011) :2 , p. 112-117
ISSN
1661-7800
ISI
000284158900006
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Background: A considerable local variability in the rate of bronchopulmonary dysplasia (BPD) has been recorded previously. Objectives: The objectives of the present study were to describe regional differences in the rate of BPD in very preterm neonates from a European population-based cohort and to further delineate risk factors. Methods: 4,185 survivors to 36 weeks postmenstrual age of 4,984 live-born infants born at 24+031+6 weeks gestation in 2003 (the MOSAIC cohort) in 10 European regions were enrolled using predefined structured questionnaires. Results: Overall median gestational age of preterms without BPD was 30 weeks (range 2331), median birth weight 1,320 g (range 4903,150) compared with 27 weeks (2331) and 900 g (3702,460) in those with BPD. The region-specific crude rate of BPD ranged from 10.2% (Italian region) to 24.8% (UK Northern region). Maternal hypertension, immaturity, male gender, small for gestational age, Apgar <7 and region of care were associated with an increased incidence of BPD on multivariate analysis. Conclusion: A wide variability of BPD between European regions may be explained by different local practices; the strongest association however was with degree of immaturity.
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