Publication
Title
Role of cell cycle perturbations in the combination therapy of chemotherapeutic agents and radiation
Author
Abstract
The combination of radiotherapy with chemotherapeutic agents that sensitize tumor cells to ionizing radiation has long been regarded as a promising strategy to enhance cancer therapy. Many chemotherapeutic agents interact with radiation and enhance the cytotoxic or anti-tumor effect of radiation through a number of mechanisms. These include an increase in initial radiation damage, inhibition of cellular repair, cell cycle redistribution, enhancement of apoptosis, counteracting hypoxia and overcoming accelerated repopulation. This article focuses on the role of cell cycle perturbations in the radiosensitivity of cancer cells.
Language
English
Source (journal)
Future oncology
Publication
2010
ISSN
1479-6694
1744-8301
Volume/pages
6:9(2010), p. 1485-1496
ISI
000283110400015
Full text (Publisher's DOI)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 25.10.2010
Last edited 03.11.2017
To cite this reference