Publication
Title
‐adjuvanted influenza A (H1N1) 2009 vaccine for adults up to 85 years of age
Author
Abstract
Background.Vaccination of high‐risk groups was started shortly after the emergence of the influenza A (H1N1) 2009 pandemic virus. Methods.Healthy adults were enrolled into 2 age strata: 1860 years and >60 years, and received monovalent influenza vaccine containing 3.75 μg of A/California/2009 (H1N1) hemagglutinin antigen, adjuvanted with AS03A. Hemagglutination inhibition assaybased antibody titers against H1N1 vaccine were assessed after 1 vaccine dose (primary endpoint), after which subjects were randomized 1:1 to receive no further vaccination or a second dose. Immunogenicity endpoints were European licensure criteria for influenza vaccines. Exploratory analyses assessed the effect of previous seasonal influenza vaccination on responses to the H1N1 vaccine. Results.Licensure criteria for immunogenicity were fulfilled after 1 dose of H1N1 vaccine ( ). For subjects 1860 years of age, previous vaccination against seasonal influenza within the preceding 2 seasons resulted in significantly lower geometric mean titers (adjusted for baseline antibody titer) after 1 or 2 doses of H1N1 vaccine ( and , respectively). Transient mild or moderate injection‐site pain was reported by 87.5% and 65.0% of subjects 1860 years of age and >60 years of age, respectively, after the first dose, and in 63% of subjects overall after the second dose. Conclusions.A single dose of 3.75 μg hemagglutinin antigen, AS03A‐adjuvanted H1N1 2009 vaccine was immunogenic and well tolerated in adults. In exploratory analyses (of subjects 1860 years of age), postvaccination antibody titers were lower in subjects who had previously received seasonal influenza vaccination, compared with those who had not. This phenomenon warrants further investigation.
Language
English
Source (journal)
Clinical infectious diseases. - Chicago, Ill.
Publication
Chicago, Ill. : 2010
ISSN
1058-4838
Volume/pages
51:6(2010), p. 668-677
ISI
000281143400005
Full text (Publisher's DOI)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 09.11.2010
Last edited 21.06.2017
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