Title
C-2 arylation of piperidines through directed transition-metal-catalyzed <tex>$sp^{3}$</tex> C--H activation C-2 arylation of piperidines through directed transition-metal-catalyzed <tex>$sp^{3}$</tex> C--H activation
Author
Faculty/Department
Faculty of Sciences. Chemistry
Publication type
article
Publication
Weinheim ,
Subject
Physics
Chemistry
Source (journal)
Chemistry: a European journal. - Weinheim
Volume/pages
16(2010) :44 , p. 13063-13067
ISSN
0947-6539
ISI
000285230000009
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
All you need is an open vial! The direct α arylation of cyclic alkylamines (see scheme) requires an open vial, as the hydrogen atom involved in the C(sp3)H-activation process is ultimately released as hydrogen gas. Reports on the formation of hydrogen gas in direct transition-metal-catalyzed functionalizations are still rare. Open-vial reactions proved crucial to this direct arylation procedure as, upon sealing, catalyst deactivation occurs.
E-info
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