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Title
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C-2 arylation of piperidines through directed transition-metal-catalyzed C--H activation
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Author
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Abstract
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| All you need is an open vial! The direct α arylation of cyclic alkylamines (see scheme) requires an open vial, as the hydrogen atom involved in the C(sp3)H-activation process is ultimately released as hydrogen gas. Reports on the formation of hydrogen gas in direct transition-metal-catalyzed functionalizations are still rare. Open-vial reactions proved crucial to this direct arylation procedure as, upon sealing, catalyst deactivation occurs. |
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Language
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English
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Source (journal)
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Chemistry: a European journal. - Weinheim
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Publication
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Weinheim
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2010
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ISSN
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0947-6539
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Volume/pages
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16
:44
(2010)
, p. 13063-13067
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ISI
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000285230000009
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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