Left/right inversion (**situs inversus cordis**) induced by displaced Raubers sickle material in the chick blastoderm
Faculty of Applied Economics
Faculty of Medicine and Health Sciences
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences . Biomedical Sciences
Trends in developmental biology
, p. 41-47
University of Antwerp
In the present report we demonstrate that the spreading of Raubers (Kollers) sickle material, the early primary organizer of the primitive streak and Hensens node (secundary organizer), also influences left/right asymmetry. Our study indicates that asymmetrically disposed Raubers sickle material (placed circularly in the prolongation of one of the sickle horns (mainly the left) of unincubated chicken blastoderms has, after culture, without mediation of a primitive streak or Hensens node, an influence on the developing asymmetry of the coelomo-cardiovascular system, by inverting its left/right axis.