Publication
Title
The **CALHM1** P86L polymorphism is a genetic modifier of age at onset in Alzheimer's disease: a meta-analysis study
Author
Abstract
The only established genetic determinant of non-Mendelian forms of Alzheimers disease (AD) is the ε4 allele of the apolipoprotein E gene (APOE). Recently, it has been reported that the P86L polymorphism of the calcium homeostasis modulator 1 gene (CALHM1) is associated with the risk of developing AD. In order to independently assess this association, we performed a meta-analysis of 7,873 AD cases and 13,274 controls of Caucasian origin (from a total of 24 centers in Belgium, Finland, France, Italy, Spain, Sweden, the UK, and the USA). Our results indicate that the CALHM1 P86L polymorphism is likely not a genetic determinant of AD but may modulate age of onset by interacting with the effect of the ε4 allele of the APOE gene.
Language
English
Source (journal)
Journal of Alzheimer's disease
Publication
2010
ISSN
1387-2877
Volume/pages
22:1(2010), p. 247-255
ISI
000283294100021
Full text (Publisher's DOI)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 07.12.2010
Last edited 03.11.2017
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