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Title
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The **CALHM1** P86L polymorphism is a genetic modifier of age at onset in Alzheimer's disease: a meta-analysis study
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Author
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Abstract
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| The only established genetic determinant of non-Mendelian forms of Alzheimers disease (AD) is the ε4 allele of the apolipoprotein E gene (APOE). Recently, it has been reported that the P86L polymorphism of the calcium homeostasis modulator 1 gene (CALHM1) is associated with the risk of developing AD. In order to independently assess this association, we performed a meta-analysis of 7,873 AD cases and 13,274 controls of Caucasian origin (from a total of 24 centers in Belgium, Finland, France, Italy, Spain, Sweden, the UK, and the USA). Our results indicate that the CALHM1 P86L polymorphism is likely not a genetic determinant of AD but may modulate age of onset by interacting with the effect of the ε4 allele of the APOE gene. |
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Language
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English
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Source (journal)
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Journal of Alzheimer's disease. - -
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Publication
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2010
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ISSN
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1387-2877
1875-8908
[Electronic]
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DOI
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10.3233/JAD-2010-100933
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Volume/pages
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22
:1
(2010)
, p. 247-255
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ISI
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000283294100021
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Full text (Publisher's DOI)
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