Title
Cervical cytology biobanking in Europe
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Milano ,
Subject
Human medicine
Source (journal)
International journal of biological markers. - Milano
Volume/pages
26(2010) :3 , p. 117-125
ISSN
0393-6155
ISI
000284394000001
Carrier
E
Target language
English (eng)
Affiliation
University of Antwerp
Abstract
A cervical cytology biobank (CCB) is an extension of current cytopathology laboratory practice consisting in the systematic storage of Pap smears or liquid-based cytology samples from women participating in cervical cancer screening with the explicit purpose to facilitate future scientific research and quality audit of preventive services. A CCB should use an internationally agreed uniform cytology terminology, be integrated in a national or regional screening registry, and be linked to other registries (histology, cancer, vaccination). Legal and ethical principles concerning personal integrity and data safety must be respected strictly. Biobank-based studies require approval of ethical review boards. A CCB is an almost inexhaustible resource for fundamental and applied biological research. In particular, it can contribute to answering questions on the natural history of HPV infection and HPV-induced lesions and cancers, screening effectiveness, exploration of new biomarkers, and surveillance of the short- and long-term effects of the introduction of HPV vaccination. To understand the limitations of CCB, more studies are needed on the quality of samples in relation to sample type, storage procedures, and duration of storage.
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