Title
Safety concerns for the use of calcium channel blockers in pregnancy for the treatment of spontaneous preterm labour and hypertension: a systematic review and meta-regression analysis Safety concerns for the use of calcium channel blockers in pregnancy for the treatment of spontaneous preterm labour and hypertension: a systematic review and meta-regression analysis
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
New York, N.Y. ,
Subject
Human medicine
Source (journal)
The journal of maternal-fetal and neonatal medicine. - New York, N.Y., 2005, currens
Volume/pages
23(2010) :9 , p. 1030-1038
ISSN
1476-7058
ISI
000282080400014
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Background.Calcium channel blockers (CCBs) are not licensed for use in pregnancy but are used without robust surveillance to treat hypertension in pregnancy and preterm labour. The objective of this study was to evaluate the fetomaternal safety of CCB in pregnancy by a quantitative systematic review. Methods.Medline (19962005), EMBASE (19962003), BIOSIS (19932003), Current contents (19952003), DERWENT DRUGFILE (19832003) and Cochrane Library (2005: issue 3). The number of women reporting an adverse event was used to compute a percentage of the total number of women in whom the occurrence of that event or confirmation of its absence was reported. Meta-regression with generalised estimation equations modelling explored reasons for heterogeneity, seeking factors that increased the rates of the most commonly reported adverse events. Findings.Of 269 relevant reports, including 5607 women, adverse fetomaternal events varied according to the total dose of nifedipine and study design. Adverse events were highest amongst women given more than 60mg total dose of nifedipine [odds ratio (OR) 3.78, 95% confidence interval (CI) 1.2711.2, p=0.017] and in reports from case series compared to controlled studies (OR 2.45, 95% CI 1.175.15, p=0.018).
E-info
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