Title
Antimalarial activity of extract and norbergenin derivatives from the stem bark of **Diospyros sanza-minika** A. Chevalier (Ebenaceae) Antimalarial activity of extract and norbergenin derivatives from the stem bark of **Diospyros sanza-minika** A. Chevalier (Ebenaceae)
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Pharmacy
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences . Biomedical Sciences
Publication type
article
Publication
London ,
Subject
Chemistry
Pharmacology. Therapy
Source (journal)
Phytotherapy research. - London
Volume/pages
24(2010) :11 , p. 1676-1679
ISSN
0951-418X
ISI
000283794300016
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
The methanol extract from the stem bark of Diospyros sanza-minika as well as five norbergenin derivatives isolated from this crude extract were evaluated for their in vitro activity against Plasmodium falciparum K1 and cytotoxicity on MRC-5 cells. 4-O-(3′-methylgalloyl)norbergenin was found to be the most potent compound (IC50 0.6 μg/mL; CC50 24.7 μg/mL), followed by 4-O-galloylnorbergenin (IC50 3.9 μg/mL; CC50 > 64 μg/mL) and 11-O-p-hydroxy-benzoyl-norbergenin (IC50 4.9 μg/mL; CC50 > 64 μg/mL). Norbergenin and 4-O-syringoylnorbergenin were inactive (IC50 > 32 μg/mL; CC50 > 64 μg/mL). The antimalarial activity of the pure constituents and of the methanol extract from the stem bark of Diospyros sanza-minika is reported for the first time. The results provide interesting baseline information for the potential use of the crude extract well as some of the isolated compounds in the search for novel antimalarial compounds.
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