Publication
Title
Antimalarial activity of extract and norbergenin derivatives from the stem bark of **Diospyros sanza-minika** A. Chevalier (Ebenaceae)
Author
Abstract
The methanol extract from the stem bark of Diospyros sanza-minika as well as five norbergenin derivatives isolated from this crude extract were evaluated for their in vitro activity against Plasmodium falciparum K1 and cytotoxicity on MRC-5 cells. 4-O-(3′-methylgalloyl)norbergenin was found to be the most potent compound (IC50 0.6 μg/mL; CC50 24.7 μg/mL), followed by 4-O-galloylnorbergenin (IC50 3.9 μg/mL; CC50 > 64 μg/mL) and 11-O-p-hydroxy-benzoyl-norbergenin (IC50 4.9 μg/mL; CC50 > 64 μg/mL). Norbergenin and 4-O-syringoylnorbergenin were inactive (IC50 > 32 μg/mL; CC50 > 64 μg/mL). The antimalarial activity of the pure constituents and of the methanol extract from the stem bark of Diospyros sanza-minika is reported for the first time. The results provide interesting baseline information for the potential use of the crude extract well as some of the isolated compounds in the search for novel antimalarial compounds.
Language
English
Source (journal)
Phytotherapy research. - London
Publication
London : 2010
ISSN
0951-418X
Volume/pages
24:11(2010), p. 1676-1679
ISI
000283794300016
Full text (Publisher's DOI)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 26.01.2011
Last edited 14.07.2017
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