Title
Lung ischemia-reperfusion injury : a molecular and clinical view on a complex pathophysiological process Lung ischemia-reperfusion injury : a molecular and clinical view on a complex pathophysiological process
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Bethesda, Md ,
Subject
Human medicine
Source (journal)
American journal of physiology: heart and circulatory physiology. - Bethesda, Md
Volume/pages
299(2010) :5 , p. 1283-1299
ISSN
0363-6135
0363-6135
ISI
000283649000001
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Lung ischemia-reperfusion injury remains one of the major complications after cardiac bypass surgery and lung transplantation. Due to its dual blood supply system and the availability of oxygen from alveolar ventilation, the pathogenetic mechanisms of ischemia-reperfusion injury in the lungs are more complicated than in other organs, where loss of blood flow automatically leads to hypoxia. In this review, an extensive overview is given of the molecular and cellular mechanisms that are involved in the pathogenesis of lung ischemia-reperfusion injury and the possible therapeutic strategies to reduce or prevent it. In addition, the roles of neutrophils, alveolar macrophages, cytokines, and chemokines, as well as the alterations in the cell-death related pathways, are described in detail.
E-info
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