Title
Interfacing neurons with carbon nanotubes : electrical signal transfer and synaptic stimulation in cultured brain circuitsInterfacing neurons with carbon nanotubes : electrical signal transfer and synaptic stimulation in cultured brain circuits
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences . Biomedical Sciences
Publication type
article
Publication
Baltimore, Md,
Subject
Biology
Human medicine
Source (journal)
The journal of neuroscience. - Baltimore, Md
Volume/pages
23(2007):26, p. 6931-6936
ISSN
0270-6474
1529-2401
ISI
000247619600008
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Abstract
The unique properties of single-wall carbon nanotubes (SWNTs) and the application of nanotechnology to the nervous system may have a tremendous impact in the future developments of microsystems for neural prosthetics as well as immediate benefits for basic research. Despite increasing interest in neuroscience nanotechnologies, little is known about the electrical interactions between nanomaterials and neurons. We developed an integrated SWNTneuron system to test whether electrical stimulation delivered via SWNT can induce neuronal signaling. To that aim, hippocampal cells were grown on pure SWNT substrates and patch clamped. We compared neuronal responses to voltage steps delivered either via conductive SWNT substrates or via the patch pipette. Our experimental results, supported by mathematical models to describe the electrical interactions occurring in SWNTneuron hybrid systems, clearly indicate that SWNTs can directly stimulate brain circuit activity.
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