Fast calculation of short-term depressing synaptic conductancesFast calculation of short-term depressing synaptic conductances
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences . Biomedical Sciences
1999Cambridge, Mass., 1999
Neural computation. - Cambridge, Mass.
11(1999):6, p. 1413-1426
An efficient implementation of synaptic transmission models in realistic network simulations is an important theme of computational neuroscience. The amount of CPU time required to simulate synaptic interactions can increase as the square of the number of units of such networks, depending on the connectivity convergence. As a consequence, any realistic description of synaptic phenomena, incorporating biophysical details, is computationally highly demanding. We present a consolidating algorithm based on a biophysical extended model of ligand-gated postsynaptic channels, describing short-term plasticity such as synaptic depression. The considerable speedup of simulation times makes this algorithm suitable for investigating emergent collective effects of short-term depression in large-scale networks of model neurons.