Publication
Title
Electrophysiological activity to cell metabolism signal transduction : possible feedback regulatory biochemical pathways
Author
Abstract
Intracellular free calcium concentration [Ca2+]IN has been extensively studied as a major feedback element, transducing endogenous levels of electrical activity into an intracellular signal, in the context of modeling activity-dependent changes of ionic conductances of a neuronal membrane patch through slow biochemical subcellular mechanisms. However, distinct patterns of activity may induce similar mean levels in [Ca2+]IN so that a multiple sensing mechanism, integrating and matching the features of calcium temporal dynamics over various time scales, is needed to overcome such ambiguous situations. In the present research, we investigate the possible role of a metabolic sensor, related to the power dissipated by the passive ion transport through channels, as an alternative candidate in intracellular calcium independent signal transduction of the electrophysiological activity.
Language
English
Source (journal)
Neurocomputing: an international journal. - Amsterdam
Publication
Amsterdam : 2001
ISSN
0925-2312
Volume/pages
38/40(2001), p. 23-30
ISI
000169129200005
Full text (Publisher's DOI)
UAntwerpen
Faculty/Department
Publication type
Subject
External links
Web of Science
Record
Identification
Creation 10.02.2011
Last edited 25.06.2017