Title
Electrophysiological activity to cell metabolism signal transduction : possible feedback regulatory biochemical pathways
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences . Biomedical Sciences
Publication type
article
Publication
Amsterdam ,
Subject
Biology
Human medicine
Source (journal)
Neurocomputing: an international journal. - Amsterdam
Volume/pages
38/40(2001) , p. 23-30
ISSN
0925-2312
ISI
000169129200005
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Abstract
Intracellular free calcium concentration [Ca2+]IN has been extensively studied as a major feedback element, transducing endogenous levels of electrical activity into an intracellular signal, in the context of modeling activity-dependent changes of ionic conductances of a neuronal membrane patch through slow biochemical subcellular mechanisms. However, distinct patterns of activity may induce similar mean levels in [Ca2+]IN so that a multiple sensing mechanism, integrating and matching the features of calcium temporal dynamics over various time scales, is needed to overcome such ambiguous situations. In the present research, we investigate the possible role of a metabolic sensor, related to the power dissipated by the passive ion transport through channels, as an alternative candidate in intracellular calcium independent signal transduction of the electrophysiological activity.
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