Title
Analysis of the signals generated by networks of neurons coupled to planar arrays of microtransducers in simulated experiments Analysis of the signals generated by networks of neurons coupled to planar arrays of microtransducers in simulated experiments
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences . Biomedical Sciences
Publication type
article
Publication
Barking ,
Subject
Biology
Human medicine
Engineering sciences. Technology
Source (journal)
Biosensors and bioelectronics. - Barking, 1990, currens
Volume/pages
13(1998) :6 , p. 601-612
ISSN
0956-5663
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Abstract
Planar microelectrode arrays can be used to characterize the dynamics of networks of neurons reconstituted in vitro. In this paper simulations related to experiments of the electrical activity recording by means of planar arrays of microtransducers coupled to networks of neurons are described. First a detailed model of single and synaptically connected neurons is given, appropriate to computer simulate the action potentials of neuronal populations. Then `realistic' signals are generated. These signals are intended to reproduce, both in shape and intensity, those recorded by a microelectrode array. Typical experimental conditions are considered, and a detailed analysis given, of the bioelectronic coupling and of its influence on the shape of the recorded signals. Finally, simulated experiments dealing with dorsal root ganglia neurons are described and analysed in comparison with experimental results reported in the literature and obtained in our own laboratory. The effectiveness of the planar microelectrode technique is briefly discussed.