Title
Fine structure of morphologically well-defined type II-neurons in the enteric nervous system of the porcine small intestine revealed by immunoreactivity for CGRP Fine structure of morphologically well-defined type II-neurons in the enteric nervous system of the porcine small intestine revealed by immunoreactivity for CGRP
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences . Biomedical Sciences
Publication type
article
Publication
Basel ,
Subject
Human medicine
Source (journal)
Acta anatomica. - Basel
Volume/pages
142(1991) :1 , p. 236-241
ISSN
0001-5180
ISI
A1991GY02200007
Carrier
E
Target language
English (eng)
Affiliation
University of Antwerp
Abstract
Calcitonin gene-related peptide (CGRP)-containing perikarya and axonal processes were localized by preembedding electron-microscopic immunocytochemistry in the porcine small intestine. Immunoreactive well-defined type II neurons were localized in the plexus myentericus, and plexus submucosus externus and internus. In some cases, they were found in direct contact to the basal lamina surrounding the ganlion, thus being in close apposition to the interstitial space. The perikarya are generally larger than the immunogative nerve cell bodies and have a typical smooth outline. The electron-microscopic features of the labeled nerve processes investigated provide evidence for their axonal nature. These ultrastructural observations confirm previous light-microscopic results which showed that CGRP-containing nerve cells in the porcine small intestine belong to the neuronal population of the type II cells, the processes of which display the ultrastructural features of axons. A large number of reactive varicosities show synaptic specializations on immunonegative nerve cell bodies, suggesting that at least part of the type II neurons have post-synaptic effects on CGRP-negative neurons.
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