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Title
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Work impairment in bipolar disorder patients results from a two-year observational study (EMBLEM)
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Author
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Institution/Organisation
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EMBLEM Advisory Board
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Abstract
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| Objectives To explore factors associated with work impairment at 2 years following an acute episode. Methods European Mania in Bipolar disorder Longitudinal Evaluation of Medication (EMBLEM) is a prospective, observational study on the outcomes of patients with a manic/mixed episode. Work impairment was measured using a Longitudinal Interval Follow-up Evaluation (slice of LIFE) item and patients were categorised with either low or high work impairment at each observation. Baseline factors associated with work impairment at 2 years were assessed using multivariate modelling. Results At baseline (n = 2289), 69% of patients had high work impairment. At 2 years (n = 1393), high impairment reduced to 41%. Modelling identified rapid cycling as the strongest disease-related factor associated with high work impairment at 2 years, although high work impairment at baseline had the strongest association overall. Lower levels of education, recent admissions, CGI-BP overall severity in the 12 months prior to baseline and CGI-BP mania at baseline all predicted higher work impairment. Living together in a relationship and independent housing were both significantly associated with having low work impairment at 2 years. Conclusions Work impairment in bipolar disorder is maintained over long periods, and is strongly associated with relationship status, living conditions and various disease-related factors. |
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Language
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English
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Source (journal)
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European psychiatry : the journal of the Association of European Psychiatrists. - Paris, 1991, currens
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Publication
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Paris
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Elsevier
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2010
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ISSN
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0924-9338
[print]
1778-3585
[online]
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DOI
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10.1016/J.EURPSY.2010.01.001
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Volume/pages
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25
:6
(2010)
, p. 338-344
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ISI
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000283107400007
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Full text (Publisher's DOI)
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