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Title
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Effects on cognitive functioning after olanzapineziprasidone crossover in recent-onset schizophrenia
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Author
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Abstract
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| Introduction To enhance functional outcome in schizophrenia improvement of cognitive symptoms is crucial. Experimental procedures Using a comprehensive test battery, this follow-up examines cognitive effects in patients with recent-onset schizophrenia after a change of medication following insufficient clinical response and intolerance. Results After eight weeks cognitive outcomes had not improved in the patients having switched from olanzapine to ziprasidone (n = 11; mean dose 136 mg) nor in those having switched from ziprasidone to olanzapine (n = 10; mean 16 mg), while the symptoms of patients maintaining olanzapine (n = 18; mean 10.9 mg) or ziprasidone (n = 18; mean 88.9 mg) treatment had not improved further. Discussion The findings suggest that also in early-stage schizophrenia the antipsychotics tested affect cognitive symptoms similarly. |
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Language
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Dutch
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Source (journal)
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European neuropsychopharmacology. - Amsterdam
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Publication
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Amsterdam
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2010
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ISSN
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0924-977X
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DOI
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10.1016/J.EURONEURO.2010.08.003
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Volume/pages
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20
:12
(2010)
, p. 907-912
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ISI
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000284569600009
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Full text (Publisher's DOI)
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