Title
Effects on cognitive functioning after olanzapineziprasidone crossover in recent-onset schizophrenia Effects on cognitive functioning after olanzapineziprasidone crossover in recent-onset schizophrenia
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Amsterdam ,
Subject
Human medicine
Source (journal)
European neuropsychopharmacology. - Amsterdam
Volume/pages
20(2010) :12 , p. 907-912
ISSN
0924-977X
ISI
000284569600009
Carrier
E
Target language
Dutch (dut)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Introduction To enhance functional outcome in schizophrenia improvement of cognitive symptoms is crucial. Experimental procedures Using a comprehensive test battery, this follow-up examines cognitive effects in patients with recent-onset schizophrenia after a change of medication following insufficient clinical response and intolerance. Results After eight weeks cognitive outcomes had not improved in the patients having switched from olanzapine to ziprasidone (n = 11; mean dose 136 mg) nor in those having switched from ziprasidone to olanzapine (n = 10; mean 16 mg), while the symptoms of patients maintaining olanzapine (n = 18; mean 10.9 mg) or ziprasidone (n = 18; mean 88.9 mg) treatment had not improved further. Discussion The findings suggest that also in early-stage schizophrenia the antipsychotics tested affect cognitive symptoms similarly.
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