Publication
Title
Effects on cognitive functioning after olanzapineziprasidone crossover in recent-onset schizophrenia
Author
Abstract
Introduction To enhance functional outcome in schizophrenia improvement of cognitive symptoms is crucial. Experimental procedures Using a comprehensive test battery, this follow-up examines cognitive effects in patients with recent-onset schizophrenia after a change of medication following insufficient clinical response and intolerance. Results After eight weeks cognitive outcomes had not improved in the patients having switched from olanzapine to ziprasidone (n = 11; mean dose 136 mg) nor in those having switched from ziprasidone to olanzapine (n = 10; mean 16 mg), while the symptoms of patients maintaining olanzapine (n = 18; mean 10.9 mg) or ziprasidone (n = 18; mean 88.9 mg) treatment had not improved further. Discussion The findings suggest that also in early-stage schizophrenia the antipsychotics tested affect cognitive symptoms similarly.
Language
Dutch
Source (journal)
European neuropsychopharmacology. - Amsterdam
Publication
Amsterdam : 2010
ISSN
0924-977X
Volume/pages
20:12(2010), p. 907-912
ISI
000284569600009
Full text (Publisher's DOI)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 22.02.2011
Last edited 06.08.2017
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