Title
Translation of randomised controlled trial findings into clinical practice : comparison of olanzapine and valproate in the EMBLEM study
Author
Contributor
Sabbe, B.
et al.
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Stuttgart ,
Subject
Human medicine
Source (journal)
Pharmacopsychiatry. - Stuttgart
Volume/pages
42(2009) :4 , p. 145-152
ISSN
0176-3679
ISI
000268143700004
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Objectives: The aim of this study was to compare the outcomes of olanzapine- and valproate-treated patients in an observational study of acute mania with the results of a randomised controlled trial (RCT) assessing the same treatments. Methods: EMBLEM (European Mania in Bipolar Evaluation of Medication) was a 2-year, prospective, observational study of health outcomes associated with the treatment of mania. Severity of mania and depression were assessed at baseline and 6 weeks using the YMRS and the 5-item version of the HAMD, respectively. Results: 621 patients were analysed (n=107 valproate, n=514 olanzapine). Both groups improved from baseline to 6 weeks in mean YMRS and HAMD-5 total scores, with greater mean improvements in the olanzapine compared with the valproate group. Olanzapine was associated with more weight gain and less gastrointestinal difficulties than valproate. Discussion: The EMBLEM results support those of the RCT, which suggest that olanzapine monotherapy seems to be more effective than valproate monotherapy in the treatment of acute mania.
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