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Title
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Translation of randomised controlled trial findings into clinical practice : comparison of olanzapine and valproate in the EMBLEM study
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Author
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Institution/Organisation
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EMBLEM Advisory Board
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Abstract
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| Objectives: The aim of this study was to compare the outcomes of olanzapine- and valproate-treated patients in an observational study of acute mania with the results of a randomised controlled trial (RCT) assessing the same treatments. Methods: EMBLEM (European Mania in Bipolar Evaluation of Medication) was a 2-year, prospective, observational study of health outcomes associated with the treatment of mania. Severity of mania and depression were assessed at baseline and 6 weeks using the YMRS and the 5-item version of the HAMD, respectively. Results: 621 patients were analysed (n=107 valproate, n=514 olanzapine). Both groups improved from baseline to 6 weeks in mean YMRS and HAMD-5 total scores, with greater mean improvements in the olanzapine compared with the valproate group. Olanzapine was associated with more weight gain and less gastrointestinal difficulties than valproate. Discussion: The EMBLEM results support those of the RCT, which suggest that olanzapine monotherapy seems to be more effective than valproate monotherapy in the treatment of acute mania. |
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Language
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English
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Source (journal)
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Pharmacopsychiatry. - Stuttgart
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Publication
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Stuttgart
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2009
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ISSN
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0176-3679
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DOI
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10.1055/S-0028-1128115
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Volume/pages
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42
:4
(2009)
, p. 145-152
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ISI
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000268143700004
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Full text (Publisher's DOI)
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