Publication
Title
Translation of randomised controlled trial findings into clinical practice : comparison of olanzapine and valproate in the EMBLEM study
Author
Institution/Organisation
EMBLEM Advisory Board
Abstract
Objectives: The aim of this study was to compare the outcomes of olanzapine- and valproate-treated patients in an observational study of acute mania with the results of a randomised controlled trial (RCT) assessing the same treatments. Methods: EMBLEM (European Mania in Bipolar Evaluation of Medication) was a 2-year, prospective, observational study of health outcomes associated with the treatment of mania. Severity of mania and depression were assessed at baseline and 6 weeks using the YMRS and the 5-item version of the HAMD, respectively. Results: 621 patients were analysed (n=107 valproate, n=514 olanzapine). Both groups improved from baseline to 6 weeks in mean YMRS and HAMD-5 total scores, with greater mean improvements in the olanzapine compared with the valproate group. Olanzapine was associated with more weight gain and less gastrointestinal difficulties than valproate. Discussion: The EMBLEM results support those of the RCT, which suggest that olanzapine monotherapy seems to be more effective than valproate monotherapy in the treatment of acute mania.
Language
English
Source (journal)
Pharmacopsychiatry. - Stuttgart
Publication
Stuttgart : 2009
ISSN
0176-3679
Volume/pages
42:4(2009), p. 145-152
ISI
000268143700004
Full text (Publishers DOI)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 22.02.2011
Last edited 30.04.2017
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