Title
The basophil activation tests in drug allergy The basophil activation tests in drug allergy
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Subject
Human medicine
Source (journal)
Revue Franšaise d'Allergologie
Volume/pages
51(2011) :3 , p. 192-193
ISSN
1877-0320
ISI
000290461300015
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
This review intends to summarize the application of the basophil activation test (BAT) in the diagnostic management of drug allergy. The BAT relies upon flow cytometric quantification of alterations of particular basophilic activation markers. In the context of drug allergy the BAT has been proven reliable to diagnose allergy from neuromuscular blocking agents, b-lactam antibiotics, chlorhexidine, plasma expanders and dyes. Moreover, the technique has proven to be complementary to skin tests in the assessment of cross-reactivity and tailoring safe alternative regimens.
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