Publication
Title
The potential of metabolomics for **Leishmania** research in the post-genomics era
Author
Abstract
The post-genomics era has provided researchers with access to a new generation of tools for the global characterization and understanding of pathogen diversity. This review provides a critical summary of published Leishmania post-genomic research efforts to date, and discusses the potential impact of the addition of metabolomics to the post-genomic toolbox. Metabolomics aims at understanding biology by comprehensive metabolite profiling. We present an overview of the design and interpretation of metabolomics experiments in the context of Leishmania research. Sample preparation, measurement techniques, and bioinformatics analysis of the generated complex datasets are discussed in detail. To illustrate the concepts and the expected results of metabolomics analyses, we also present an overview of comparative metabolic profiles of drug-sensitive and drug-resistant Leishmania donovani clinical isolates.
Language
English
Source (journal)
Parasitology. - London, 1908, currens
Publication
London : 2010
ISSN
0031-1820 [print]
1469-8161 [online]
Volume/pages
137:9(2010), p. 1291-1302
ISI
000280418400003
Full text (Publisher's DOI)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 23.02.2011
Last edited 16.06.2017
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