Publication
Title
Attenuated atherogenesis in apolipoprotein E-deficient mice lacking amyloid precursor protein
Author
Abstract
Objective Recent evidence suggests that amyloid precursor protein (APP) is overexpressed in atherosclerosis-prone regions of mouse aorta. We therefore investigated in the present study whether APP has a role in the progression and composition of atherosclerotic plaques. Methods and results Apolipoprotein E-deficient (apoE−/−) mice were crossbred with animals lacking APP (APP−/−). After 16 weeks on a Western-type diet, apoE−/− and APP−/−/apoE−/− mice showed similar cholesterol levels. However, atherosclerotic plaque size was significantly reduced in the distal thoracic aorta (90% reduction) and abdominal aorta (75% reduction) of APP−/−/apoE−/− mice as compared to apoE−/−. Plaques at the level of the aortic valves were not different in size, but showed a more stable phenotype in APP−/−/apoE−/− mice, as indicated by a reduced macrophage content, an increased amount of collagen and a thicker fibrous cap. Conclusion Our findings provide evidence that lack of APP attenuates atherogenesis and leads to plaque stability.
Language
English
Source (journal)
Atherosclerosis. - Amsterdam
Publication
Amsterdam : 2011
ISSN
0021-9150
Volume/pages
216:1(2011), p. 54-58
ISI
000290205800009
Full text (Publishers DOI)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 01.03.2011
Last edited 26.05.2017
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