Title
Component-resolved allergy diagnosis : a new era? Component-resolved allergy diagnosis : a new era?
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Brussel ,
Subject
Human medicine
Source (journal)
Verhandelingen / Koninklijke Academie voor Geneeskunde van BelgiŽ. - Brussel, 1973 - 2011
Volume/pages
(2011)
ISSN
0372-610X
0302-6469
Carrier
E
Target language
English (eng)
Affiliation
University of Antwerp
Abstract
During the last decades a new in vitro technique has entered the field of allergy diagnosis, that is, component-resolved allergy diagnosis (CRD). In contrast to traditional specific IgE (sIgE) assays, CRD does not rely upon whole extract preparations from native allergens but on quantification of sIgE antibodies to single protein components, purified from natural sources or obtained by recombinant techniques. At present, it emerges that CRD can improve management of the allergic patient as it allows (to some extent) to discriminate between clinically significant and irrelevant sIgE result and to establish sensitization patterns with particular prognostic outcomes. Nevertheless, further clinical validation is mandatory before the technique can enter mainstream application. By no means can CRD currently be considered as a substitute to traditional sIgE assays.
E-info
https://repository.uantwerpen.be/docman/iruaauth/6b37eb/bbdee479cb6.pdf
Handle