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Title
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Herbal medicines and infectious diseases : characterization by LC-SPE-NMR of some medicinal plant extracts used against malaria
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Author
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Abstract
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| The extracts of two medicinal plants used in traditional medicine against malaria were characterized by means of an LC-SPE-NMR and LC-MS platform. The structure of a series of major constituents from Bafodeya benna, as well as minor constituents from Ormocarpum kirkii, was determined. Bafodeya benna was found to contain (2R,3R)-taxifolin-3-O-α-L-rhamnoside or astilbin, and its isomers neoastilbin, neoisoastilbin, and isoastilbin, as well as quercetin-3-O-α-L-rhamnoside. From Ormocarpum kirkii, a series of known flavonoids and biflavonoids was obtained, as well as three new compounds, i.e., 7,7′′-di-O-β-D-glucosyl-(−)-chamaejasmin, 7-O-β-D-glucosyl-(I-3,II-3)-biliquiritigenin, and isovitexin-(I-3,II-3)-naringenin. The isolated constituents may explain, at least in part, the traditional use against malaria. LC-SPE-NMR, in combination with LC-MS, is a powerful tool for the fast characterization of plant extracts, in order to define priorities at an early stage of a fractionation procedure. In addition, herbal medicinal products can completely be characterized, both with regard to their major as well as their minor constituents. |
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Language
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English
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Source (journal)
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Planta medica: natural products and medicinal plant research. - Stuttgart
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Publication
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Stuttgart
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2011
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ISSN
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0032-0943
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DOI
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10.1055/S-0030-1270719
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Volume/pages
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77
:11
(2011)
, p. 1139-1148
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ISI
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000293007700009
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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