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Title
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Synthesis and antiplasmodial activity of highly active reverse analogues of the antimalarial drug candidate fosmidomycin
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Author
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Abstract
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| Inhibition of enzymes involved in the nonmevalonate pathway of isoprenoid biosynthesis represents a promising strategy for the development of novel antimalarial agents. A small series of reverse hydroxamate-based fosmidomycin analogues was synthesized and evaluated for their inhibitory activity against the recombinant 1-deoxy-D-xylulose 5-phosphate reductoisomerases (DXRs) of Escherichia coli and Plasmodium falciparum, as well as for their in vitro antiplasmodial activity and cytotoxicity. |
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Language
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English
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Source (journal)
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ChemMedChem. - Place of publication unknown
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Publication
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Place of publication unknown
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2010
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ISSN
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1860-7179
[print]
1860-7187
[online]
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DOI
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10.1002/CMDC.201000276
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Volume/pages
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5
:10
(2010)
, p. 1673-1676
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ISI
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000283670200004
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Full text (Publisher's DOI)
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