Title
Relationship between baseline blood pressure parameters (including mean pressure, pulse pressure, and variability) and early outcome after stroke : data from the Tinzaparin in Acute Ischaemic Stroke Trial (TAIST)
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences . Biomedical Sciences
Publication type
article
Publication
New York, N.Y. ,
Subject
Human medicine
Source (journal)
Stroke: a journal of cerebral circulation / American Heart Association. - New York, N.Y.
Volume/pages
42(2011) :2 , p. 491-493
ISSN
0039-2499
ISI
000286509400049
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Background and PurposeHigh blood pressure (BP) in acute stroke is associated independently with a poor outcome. Recent evidence suggests that other hemodynamic parameters may also be associated with outcomes following stroke. MethodsThe relationship between baseline BP, heart rate, and other hemodynamic parameters, and early outcomes were assessed using data from TAIST trial. ResultsDeath or neurological deterioration at day 10 was associated, both in unadjusted and adjusted analyses, with systolic BP (adjusted OR, 1.02; 95% CI, 1.011.03), mean arterial pressure (OR, 1.02; 95% CI, 1.011.04), pulse pressure (OR, 1.02; 95% CI, 1.011.03), and BP variability (OR, 1.03; 95% CI, 1.011.05). Similar relationships were noted for deterioration alone, and recurrent stroke. ConclusionsEarly death or neurologic deterioration, deterioration, and recurrent stroke are associated independently with high systolic BP, mean arterial pressure, pulse pressure, and BP variability. These measures offer potential therapeutic targets for improving early outcome after acute ischemic stroke.
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