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Title
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Biochemical markers for blood-brain barrier dysfunction in acute ischemic stroke correlate with evolution and outcome
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Author
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Abstract
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| Background/Aims: We evaluated the cerebrospinal fluid/serum albumin ratio (AR) and kinetics of matrix metalloproteinase-9 (MMP-9) in blood as markers for blood-brain barrier (BBB) disruption after acute ischemic stroke. Methods: The AR was determined in 88 patients with acute ischemic stroke or transient ischemic attack. MMP-9 was measured on admission, 24, 72 h and 7 days after stroke onset. Results: The AR was related to stroke severity, the occurrence of stroke progression and the modified Rankin Scale score at month 3. MMP-9 levels on admission were significantly elevated compared to controls and dropped in the first 72 h after stroke, except in patients with stroke progression and larger infarcts in the subacute phase. Conclusions:We demonstrate that the extent of BBB breakdown in hyperacute stroke relates to initial stroke severity, stroke evolution and long-term outcome. The kinetics of MMP-9 confirm its pivotal role in secondary brain damage after ischemic stroke. |
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Language
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English
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Source (journal)
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European neurology. - Basel
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Publication
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Basel
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2011
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ISSN
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0014-3022
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DOI
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10.1159/000321965
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Volume/pages
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65
:1
(2011)
, p. 23-31
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ISI
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000286805100004
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Full text (Publisher's DOI)
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