Title
Quantitative EEG in ischemic stroke : correlation with functional status after 6 months Quantitative EEG in ischemic stroke : correlation with functional status after 6 months
Author
Faculty/Department
Administrative Services
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences . Biomedical Sciences
Publication type
article
Publication
Amsterdam ,
Subject
Human medicine
Source (journal)
Clinical neurophysiology. - Amsterdam
Volume/pages
122(2011) :5 , p. 874-883
ISSN
1388-2457
ISI
000290098700006
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Objective Stroke is a major cause of adult-onset disability and dependency. We investigated whether EEG parameters are of prognostic value for functional outcome 6 months after ischemic stroke. Methods One-hundred and ten patients presenting with acute ischemic stroke and persistent neurological deficits at EEG recording were incrementally included. Clinical characteristics, volume of ischemia and EEG parameters were correlated with functional outcome assessed with the modified Rankin Scale (mRS) score. Predictive values for disability, dependency and death were calculated using receiver operating characteristic (ROC) curves and logistic regression modeling. Results The EEG pairwise derived Brain Symmetry Index (pdBSI) and (delta + theta)/(alpha + beta) ratio (DTABR) were significantly correlated with the modified Rankin Scale (mRS) score at month 6 (Spearman ρ = 0.46 and ρ = 0.47, respectively, p < 0.0005 for both). NIHSS (OR 1.15, 95% CI 1.041.27, p = 0.005) and pdBSI (OR 4.07, 95% CI 1.3212.58, p = 0.015) were independently associated with disability 6 months after stroke. Dependency was independently indicated by NIHSS (OR 1.22, 95% CI 1.091.37, p < 0.0005) and DTABR (OR 2.25, 95% CI 1.164.37, p = 0.016). Six month mortality was independently indicated by age at stroke onset (OR 1.18, 95% CI 1.051.32, p = 0.007), NIHSS (OR 1.11, 95% CI 1.031.21, p = 0.009) and DTABR (OR 2.04, 95% CI 1.083.85, p = 0.028). Conclusions EEG in the subacute setting of ischemic stroke may be of prognostic value for disability, dependency and death after 6 months. Significance Early prognostication of functional outcome after stroke is relevant to efficient rehabilitation management to enhance recovery and minimize long-term disability.
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