Publication
Title
On the importance of an acid additive in the synthesis of pyrido[1,2-a]benzimidazoles by direct copper-catalyzed amination
Author
Abstract
Not just an acid! An expedient and highly modular synthesis of 6-, 7-, and 8-substituted pyrido[1,2-a]benzimidazoles (4) has been developed by a direct intramolecular C[BOND]H amination of N-phenylpyridin-2-amines (3). Efficient C[BOND]H amination of 3 could only be achieved in the presence of catalytic copper and an acid additive. The type of acid (pKa) proved to be crucial for the catalysis. C[BOND]Cl aminations in N-(2-chloroaryl)pyridin-2-amines allow access to 9-substituted pyrido[1,2-a]benzimidazoles.
Language
English
Source (journal)
Chemistry: a European journal. - Weinheim
Publication
Weinheim : 2011
ISSN
0947-6539
Volume/pages
17:23(2011), p. 6315-6320
ISI
000292095800005
Full text (Publisher's DOI)
Full text (publisher's version - intranet only)
UAntwerpen
Faculty/Department
Research group
[E?say:metaLocaldata.cgzprojectinf]
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 15.04.2011
Last edited 20.08.2017
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