Title
Functional connectivity fMRI of the rodent brain : comparison of functional connectivity networks in rat and mouse Functional connectivity fMRI of the rodent brain : comparison of functional connectivity networks in rat and mouse
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences . Biomedical Sciences
Publication type
article
Publication
Subject
Biology
Veterinary medicine
Source (journal)
PLoS ONE
Volume/pages
6(2011) :4 , p. e18876,1-e18876,9
ISSN
1932-6203
ISI
000289620100026
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
At present, resting state functional MRI (rsfMRI) is increasingly used in human neuropathological research. The present study aims at implementing rsfMRI in mice, a species that holds the widest variety of neurological disease models. Moreover, by acquiring rsfMRI data with a comparable protocol for anesthesia, scanning and analysis, in both rats and mice we were able to compare findings obtained in both species. The outcome of rsfMRI is different for rats and mice and depends strongly on the applied number of components in the Independent Component Analysis (ICA). The most important difference was the appearance of unilateral cortical components for the mouse resting state data compared to bilateral rat cortical networks. Furthermore, a higher number of components was needed for the ICA analysis to separate different cortical regions in mice as compared to rats.
Full text (open access)
https://repository.uantwerpen.be/docman/irua/c94b2c/2a79c236.pdf
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