Title
Peroxisome proliferator-activated receptors in squamous cell carcinoma and its precursorsPeroxisome proliferator-activated receptors in squamous cell carcinoma and its precursors
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Research group
Translational Pathophysiological Research (TPR)
Faculteit Geneeskunde
Publication type
article
Publication
Copenhagen,
Subject
Human medicine
Source (journal)
Journal of cutaneous pathology. - Copenhagen, 1974, currens
Volume/pages
32(2005):5, p. 340-347
ISSN
0303-6987
1600-0560
ISI
000228134100004
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Background:  Peroxisome proliferator-activated receptors (PPARs) mediate several functions that are of interest in carcinogenesis. Although PPARα, PPARβ, and PPARγ are expressed in multiple human, their expression has not been investigated in non-melanoma skin cancer. Methods:  We performed a retrospective paired immunohistochemical analysis of normal skin, actinic keratosis (AK), and squamous cell carcinoma (SCC) among 35 individuals. Specimens were considered PPAR immunoreactive when 1% or more of the tumor cells showed clear evidence of immunostaining. Cyclooxygenase-2 (COX-2) expression, the fraction of proliferating endothelial cells, and microvessel density were also evaluated in these samples. Results:  PPARα immunoreactivity was significantly less likely to occur in SCC and AK than in normal skin of each individual. In contrast to PPARα, PPARβ appeared to be upregulated in (pre)malignant skin lesions. For each individual, the likelihood that normal skin, AK, or SCC was immunoreactive against PPARγ was comparable. COX-2 immunopositivity was significantly associated with PPARβ and PPARγ immunoreactivity. No statistical differences were noted for the angiogenesis parameters and PPARα, PPARβ, or PPARγ expression, except that the microvessel density was significantly higher among PPARβ-immunoreactive SCCs compared to that among immunonegative SCCs. Conclusion:  Although further research is warranted, these results suggest that PPAR ligands such as fibrates and thiazolidinediones may have chemoprophylactic properties in skin carcinogenesis.
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